I’ve been on pizotifen for almost 2 years at 2.5mg per day. it does not affect my drinking at all these days. however, if you find the pizotifen makes you tired and woozy, then drinking alcohol on top can make you even more tired and woozy. i would recommend waiting until you feel “normal” on the medication and start with a small drink or two at home and see how it goes.
i wouldn’t recommend slamming ten shots of tequila like i did last month. i felt awful the next day. must be the pizotifen, right?
as far as i know, there is not biochemical reason that you can’t drink on pizotifen; rather it’s just that you are taking two things at once that can both act as physical depressants. so one pint of beer might feel like two or even four pints, as Dr S described it to me.
however, I AM NOT A DOCTOR, and i cannot ever recommend you to ignore medical advice. but if you do, try it slowly, at home on the sofa with a can of beer. worst case, the sofa is near the floor.